Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Targetβ-adrenergic agonist
General description
Phenethylamine derivative. Selective β-adrenergic agonist that increases cytosolic cAMP. Promotes glycogen breakdown and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit trachea cells through nitric oxide generation.
Phenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl– diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem.275, 25342.Carmena, M.J., et al. 1997. Prostate 33, 46.Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.Kishimoto, I., et al. 1994. J. Biol. Chem.269, 28300.Macaulay, S.L., et al. 1994. Mol. Cell Biochem.141, 27.Yashiro, K., et al. 1994. J. Biochem.115, 1040.Ladenheim, R.G., et al. 1993. J. Neurochem.60, 260.von Zastrow, M., et al. 1993. J. Biol. Chem.268, 763.Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.
Packaging
100 mg in Plastic ampoule
Reconstitution
Unstable in solution; reconstitute just prior to use.
Warning
Toxicity: Irritant (B)
This product has met the following criteria to qualify for the following awards: